AIM:-To study the effect of compression force on disintegration time.
REQUIREMENTS:
Appartus:- Beaker ,stirrer ,tablet punching machine,KBr Press,mortar and pestle.
Chemicals:-paracetamol, starch, talc , magnesium stearate, PVP.
REFERENCES:
1) Roop k. khar ,SP Vyas ,Farhan J Ahmad ,Industrial pharmacy fourth edition CBS Publisher and Distributor pvt ltd. Page no:469 ,486.
2) D. K. Tripathi Pharmaceutics basic principle and formulaton published by pharmamed press page no.:52
THEORY:
Compression force is the force generated from compressing an object or substance when shearing forces are aligned into each other they are called as compression force. Compression force is used to power everything from compression brakes to hand tools. Compression force occurs when a physical force presses inward an object, causing it to become compacted. Compression force is the application of power, pressure or exertion against on object that causes it to become squeezed, squashed or compacted. Disintegration time is the time required for a dosage form to break up into granules of specified size under careful specified condition. Literature suggests that increase in the applied pressure used to prepare a tablet leads to an increase in its disintegration time In other word an increase in tablet hardness that is the pressure applied for compression of tablet would lead to increase in tablet disintegration time which would in turn affect the drug bioavailability and its release.
Plastic compression
Elastic compression
Repacking
Ejection force
Compaction
Compression
Consolidation
Open-intra particulate voids-
Closed-intra particulate voids
Inter particulate voids Volumes
True volume
Granular volume
Bulk volume
Role Of Moisture
Interparticulate friction
Die wall friction
Force Distribution
FORMULATION TABLE:-
Sr. No.
Ingredients
Qt. given (mg)
Qt taken (mg)
Uses
1
Paracetamol
500
Antipyretic
2
Pvp
5%
Binder
3
Magnesium stearate
1%
Lubricant
4
Talc
0.5%
Glidant
5
starch
q. s. 650
Disintegrant
Result: From the above experiment it can be concluded that as the compression force of tablet increases leads to increase in the hardness thus disintegration time of the tablet increases.
Remark:
Practical Performance
(2)
Conduct in Lab
(2)
Journal
(2)
Observations and Results
(2)
Viva-Voce
(2)
Total
(10)
Signature of Faculty In charge
EXPERIMENT NO: 5
